| Filament, Intermediate filament protein | 220 genes |
| fn3, Fibronectin type III domain | 134 genes |
| FAP, Fibronectin-attachment protein (FAP). This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These prote | 51 genes |
| Fork_head, Fork head domain | 47 genes |
| FYVE, FYVE zinc finger. The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinati | 30 genes |
| F-box, F-box domain | 29 genes |
| fatty acid metabolism, IEA | 27 genes |
| Fibrinogen_C, Fibrinogen beta and gamma chains, C-terminal globular domain | 26 genes |
| FGF, Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. These growth factors cause dimerisation of their tyrosine kinase receptors leading to intrace | 25 genes |
| F5_F8_type_C, F5/8 type C domain. This domain is also known as the discoidin (DS) domain family. The bacterial examples are not yet included in the SEED alignment and are only found with low scores | 24 genes |
| Fz, Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines | 22 genes |
| Frizzled, Frizzled/Smoothened family membrane region. This family contains the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to d | 22 genes |
| FeoB, Ferrous iron transport protein B. Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transp | 22 genes |
| FHA, FHA domain. The FHA (Forkhead-associated) domain is a phosphopeptide binding motif | 20 genes |
| FKBP_C, FKBP-type peptidyl-prolyl cis-trans isomerase | 19 genes |
| FCH, Fes/CIP4 homology domain. Alignment extended from. Highly alpha-helical | 19 genes |
| fatty acid biosynthesis, IEA | 19 genes |
| frizzled-2 signaling pathway, IEA | 19 genes |
| feeding behavior, TAS | 15 genes |
| FH2, Formin Homology 2 Domain | 14 genes |
| fatty acid metabolism, TAS | 14 genes |
| fertilization (sensu Animalia), TAS | 14 genes |
| female gamete generation, TAS | 13 genes |
| fn2, Fibronectin type II domain | 12 genes |
| FMO-like, Flavin-binding monooxygenase-like. This family includes FMO proteins and cyclohexanone monooxygenase | 12 genes |
| Filamin, Filamin/ABP280 repeat | 11 genes |
| Furin-like, Furin-like cysteine rich region | 11 genes |
| frizzled signaling pathway, IEA | 11 genes |
| Ferritin, Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins | 10 genes |
| Flavodoxin_1, Flavodoxin | 10 genes |
| ferric iron binding, IEA | 10 genes |
| FA_desaturase, Fatty acid desaturase | 9 genes |
| FAD_binding_3, FAD binding domain. This domain is involved in FAD binding in a number of enzymes | 9 genes |
| Ferric_reduct, Ferric reductase like transmembrane component. This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respirat | 9 genes |
| FG-GAP, FG-GAP repeat. This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after t | 9 genes |
| fatty acid metabolism, NR | 9 genes |
| FGGY_N, FGGY family of carbohydrate kinases, N-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain | 8 genes |
| Filament_head, Intermediate filament head (DNA binding) region. This family represents the N-terminal head region of intermediate filaments. Intermediate filament heads bind DNA. Vimentin heads are able to alter nuclear architecture and chroma | 8 genes |
| fatty acid beta-oxidation, TAS | 7 genes |
| fluid secretion, TAS | 7 genes |
| FAD_binding_1, FAD binding domain. This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase | 6 genes |
| FAD_binding_6, Oxidoreductase FAD-binding domain | 6 genes |
| FTHFS, Formate--tetrahydrofolate ligase | 6 genes |
| FBA, F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. One member has been shown to be in | 6 genes |
| FAST_Leu-rich, FAST kinase leucine-rich. This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated duri | 6 genes |
| FK506 binding, TAS | 6 genes |
| folic acid binding, IEA | 6 genes |
| fibroblast growth factor receptor signaling pathway, TAS | 6 genes |
| FAD binding, IEA | 6 genes |
| FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is | 5 genes |
| FtsJ, FtsJ-like methyltransferase. This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure | 5 genes |
| FF, FF domain. This domain has been predicted to be involved in protein-protein interaction. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein i | 5 genes |
| FAT, FAT domain. The FAT domain is named after FRAP, ATM and TRRAP | 5 genes |
| FATC, FATC domain. The FATC domain is named after FRAP, ATM, TRRAP C-terminal | 5 genes |
| Fringe, Fringe-like. The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands. FNG is localised to the Golgi apparatus (not secreted as previously thought). Modificat | 5 genes |
| FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain | 5 genes |
| Folate_rec, Folate receptor family. This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to th | 5 genes |
| FYRN, F/Y-rich N-terminus. This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541 | 5 genes |
| FYRC, F/Y rich C-terminus. This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542 | 5 genes |
| Fez1, Fez1. This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. There is evidence that Fez1 inhibits canc | 5 genes |
| fibrinogen complex, TAS | 5 genes |
| fructose metabolism, TAS | 5 genes |
| frizzled signaling pathway, TAS | 5 genes |
| fertilization (sensu Animalia), IEA | 5 genes |
| folic acid and derivative biosynthesis, IEA | 5 genes |
| Formyl_trans_N, Formyl transferase. This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. | 4 genes |
| FAD_binding_2, FAD binding domain. This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase | 4 genes |
| FMN_dh, FMN-dependent dehydrogenase | 4 genes |
| FAD_binding_4, FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the ali | 4 genes |
| Folate_carrier, Reduced folate carrier. The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transpo | 4 genes |
| Fasciclin, Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria | 4 genes |
| Flotillin, Flotillin family. Flotillins are integral membrane proteins that have been shown to be present in several subcellular components, including caveolae (invaginated plasma membrane microdomains), lipid rafts (sphingolipid and cholester | 4 genes |
| Fumble, Fumble. Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes t | 4 genes |
| F420_oxidored, NADP oxidoreductase coenzyme F420-dependent | 4 genes |
| FUN14, FUN14 family. This family of short proteins are found in eukaryotes and some archaea. Although the function of these proteins is not known they may contain transmembrane helices | 4 genes |
| FragX_IP, Cytoplasmic Fragile-X interacting family. CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a highly conserved protein family. The function of CYFIPs is unclear, but CYFIP interaction with frag | 4 genes |
| FGF-BP1, FGF binding protein 1 (FGF-BP1). This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein ( | 4 genes |
| fructose-2,6-bisphosphate 2-phosphatase activity, IEA | 4 genes |
| fibroblast growth factor receptor activity, NAS | 4 genes |
| fatty acid binding, TAS | 4 genes |
| F-actin capping protein complex, TAS | 4 genes |
| folate transport, TAS | 4 genes |
| fn1, Fibronectin type I domain | 3 genes |
| Fer4_NifH, 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family | 3 genes |
| F-actin_cap_A, F-actin capping protein alpha subunit | 3 genes |
| FAD-oxidase_C, FAD linked oxidases, C-terminal domain. This domain has a ferredoxin-like fold | 3 genes |
| Fascin, Fascin protein. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two | 3 genes |
| fructose-bisphosphate aldolase activity, TAS | 3 genes |
| fatty acid binding, NR | 3 genes |
| folic acid binding, TAS | 3 genes |
| fucose metabolism, IEA | 3 genes |
| fatty acid beta-oxidation, IEA | 3 genes |
| fibroblast growth factor receptor signaling pathway, NAS | 3 genes |
| flagellum (sensu Bacteria), IEA | 3 genes |
| fatty acid oxidation, ISS | 3 genes |
| Fer4, 4Fe-4S binding domain. Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antipa | 2 genes |
| Fer2, 2Fe-2S iron-sulfur cluster binding domain | 2 genes |
| FBPase, Fructose-1-6-bisphosphatase | 2 genes |
| FAD_binding_5, FAD binding domain in molybdopterin dehydrogenase | 2 genes |
| Fibrillarin, Fibrillarin | 2 genes |
| Fer2_2, [2Fe-2S] binding domain | 2 genes |
| Flavodoxin_2, Flavodoxin-like fold. This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electr | 2 genes |
| Fe_hyd_lg_C, Iron only hydrogenase large subunit, C-terminal domain | 2 genes |
| Formyl_trans_C, Formyl transferase, C-terminal domain | 2 genes |
| FAD_binding_7, FAD binding domain of DNA photolyase | 2 genes |
| Focal_AT, Focal adhesion targeting region. Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-termin | 2 genes |
| Fructosamin_kin, Fructosamine kinase. This family includes eukaryotic fructosamine-3-kinase enzymes. The family also includes bacterial members that have not been characterised but probably have a similar or identical function | 2 genes |
| FLYWCH, FLYWCH zinc finger domain. Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The occurr | 2 genes |
| Far-17a_AIG1, FAR-17a/AIG1-like protein. This family includes the hamster androgen-induced FAR-17a protein, and its human homologue, the AIG1 protein. The function of these proteins is unknown. This family also includes homologous regions from | 2 genes |
| Fzo_mitofusin, fzo-like conserved region. Family of putative transmembrane GTPase. The fzo protein is a mediator of mitochondrial fusion. This conserved region is also found in the human mitofusin protein | 2 genes |
| Flagellar_rod, Paraflagellar rod protein. This family consists of several eukaryotic paraflagellar rod component proteins. The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains | 2 genes |
| FbpA, Fibronectin-binding protein A N-terminus (FbpA). This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infecti | 2 genes |
| FRG1, FRG1-like family. The human FRG1 gene maps to human chromosome 4q35 and has been identified as a candidate for facioscapulohumeral muscular dystrophy. Currently, the function of FRG1 is unknown | 2 genes |
| FtsH_ext, FtsH Extracellular. This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes. It only efficiently degrades proteins that have a low thermodynamic | 2 genes |
| fatty acid alpha-oxidation, TAS | 2 genes |
| fructose-2,6-bisphosphate 2-phosphatase activity, TAS | 2 genes |
| FK506 binding, NR | 2 genes |
| focal adhesion, ISS | 2 genes |
| fructose 6-phosphate metabolism, NR | 2 genes |
| fructose 6-phosphate metabolism, TAS | 2 genes |
| fructose 2,6-bisphosphate metabolism, NAS | 2 genes |
| fatty acid desaturation, TAS | 2 genes |
| fertilization (sensu Animalia), IMP | 2 genes |
| fusion of sperm to egg plasma membrane, IEA | 2 genes |
| fusion of sperm to egg plasma membrane, TAS | 2 genes |
| feeding behavior, NR | 2 genes |
| ferritin complex, TAS | 2 genes |
| F-actin capping protein complex, IEA | 2 genes |
| F-actin capping protein complex, NR | 2 genes |
| fatty acid (omega-1)-hydroxylase activity, TAS | 2 genes |
| fucosyltransferase activity, IEA | 2 genes |
| folate transporter activity, NAS | 2 genes |
| flotillin complex, IEA | 2 genes |
| fibroblast growth factor binding, IEA | 2 genes |
| fructose-bisphosphatase activity, IEA | 2 genes |
| fibrinolysis, IDA | 2 genes |
| Fe-ADH, Iron-containing alcohol dehydrogenase | 1 genes |
| Ferrochelatase, Ferrochelatase | 1 genes |
| F_actin_cap_B, F-actin capping protein, beta subunit | 1 genes |
| Fapy_DNA_glyco, Formamidopyrimidine-DNA glycosylase N-terminal domain. Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-st | 1 genes |
| Frataxin_Cyay, Frataxin-like domain. This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. Th | 1 genes |
| FAD_Synth, Riboflavin kinase / FAD synthetase. This family consists part of the bifunctional enzyme riboflavin kinase / FAD synthetase. These enzymes have both ATP:riboflavin 5'-phospho transferase and ATP:FMN-adenylyltransferase activitys. Th | 1 genes |
| Fanconi_C, Fanconi anaemia group C protein | 1 genes |
| Flavoprotein, Flavoprotein. This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyses the removal of two reduci | 1 genes |
| Fic, Fic protein family. This family consists of the Fic (filamentation induced by cAMP) protein and its relatives. The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that | 1 genes |
| Flt3_lig, flt3 ligand. The flt3 ligand is a short chain cytokine with a 4 helical bundle fold | 1 genes |
| FTCD, Formiminotransferase domain | 1 genes |
| FDX-ACB, Ferredoxin-fold anticodon binding domain. This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold | 1 genes |
| FMN_red, NADPH-dependent FMN reductase | 1 genes |
| Fanconi_A, Fanconi anaemia group A protein | 1 genes |
| FA_hydroxylase, Fatty acid hydroxylase | 1 genes |
| FTCD_C, Formiminotransferase-cyclodeaminase. Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in the C-terminus of the bifunctional animal members of the family | 1 genes |
| Fip1, Fip1 motif. This short motif is about 40 amino acids in length. In the Fip1 protein that is a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. This region of Fip1 is needed for the int | 1 genes |
| FIBP, Acidic fibroblast growth factor binding (FIBP). Acidic fibroblast growth factor (aFGF) intracellular binding protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF | 1 genes |
| FdrA, Bacterial FdrA protein. This family consists of several bacterial FdrA proteins. FdrA is known to play a role in the suppression of dominant negative FtsH proteins | 1 genes |
| Fukutin-related, Fukutin-related. Fukutin is a eukaryotic protein necessary for the maintenance of muscle integrity, cortical histiogenesis, and normal ocular development. Mutations in the fukutin gene have been shown to result in Fukuyama-typ | 1 genes |
| FAIM, Fas apoptotic inhibitory molecule (FAIM). This family consists of several fas apoptotic inhibitory molecule (FAIM) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression o | 1 genes |
| FPN1, Ferroportin1 (FPN1). This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell. This family may represent a number of tran | 1 genes |
| furin activity, TAS | 1 genes |
| farnesyl-diphosphate farnesyltransferase activity, IEA | 1 genes |
| farnesyltranstransferase activity, IEA | 1 genes |
| fatty-acyl-CoA synthase activity, TAS | 1 genes |
| ferroxidase activity, TAS | 1 genes |
| ferredoxin-NADP+ reductase activity, TAS | 1 genes |
| ferrochelatase activity, TAS | 1 genes |
| formaldehyde dehydrogenase (glutathione) activity, TAS | 1 genes |
| formate-tetrahydrofolate ligase activity, TAS | 1 genes |
| fumarate hydratase activity, TAS | 1 genes |
| fumarylacetoacetase activity, TAS | 1 genes |
| fucosylgalactoside 3-alpha-galactosyltransferase activity, NAS | 1 genes |
| follicle stimulating hormone receptor activity, IEA | 1 genes |
| follicle stimulating hormone receptor activity, TAS | 1 genes |
| fibroblast growth factor receptor activity, TAS | 1 genes |
| fibroblast growth factor receptor binding, IDA | 1 genes |
| fructose transporter activity, IEA | 1 genes |
| fructose transporter activity, TAS | 1 genes |
| fatty acid binding, ISS | 1 genes |
| fatty acid binding, NAS | 1 genes |
| fibrillar collagen, IDA | 1 genes |
| focal adhesion, NAS | 1 genes |
| fructose 2,6-bisphosphate metabolism, IEA | 1 genes |
| fructose 2,6-bisphosphate metabolism, NR | 1 genes |
| fucose metabolism, TAS | 1 genes |
| fumarate metabolism, TAS | 1 genes |
| fatty acid metabolism, IDA | 1 genes |
| fatty acid metabolism, ISS | 1 genes |
| fatty acid metabolism, NAS | 1 genes |
| fatty acid biosynthesis, NAS | 1 genes |
| fatty acid beta-oxidation, IMP | 1 genes |
| fatty acid beta-oxidation, NAS | 1 genes |
| fatty acid desaturation, NAS | 1 genes |
| FADH2 metabolism, NAS | 1 genes |
| folic acid and derivative metabolism, TAS | 1 genes |
| frizzled signaling pathway, NAS | 1 genes |
| frizzled signaling pathway, NR | 1 genes |
| female gamete generation, NR | 1 genes |
| fertilization (sensu Animalia), ISS | 1 genes |
| fertilization (sensu Animalia), NAS | 1 genes |
| fertilization (sensu Animalia), NR | 1 genes |
| fusion of sperm to egg plasma membrane, IDA | 1 genes |
| fusion of sperm to egg plasma membrane, NAS | 1 genes |
| fasciculation of neuron, NAS | 1 genes |
| fat body development, NR | 1 genes |
| fluid secretion, NR | 1 genes |
| feeding behavior, IEA | 1 genes |
| feeding behavior, ISS | 1 genes |
| ferrous iron binding, NAS | 1 genes |
| ferrous iron binding, TAS | 1 genes |
| formylmethionine deformylase activity, IEA | 1 genes |
| folate transporter activity, TAS | 1 genes |
| fibroblast growth factor receptor signaling pathway, ISS | 1 genes |
| female gonad development, TAS | 1 genes |
| ferredoxin hydrogenase activity, IEA | 1 genes |
| fatty acid catabolism, NR | 1 genes |
| flagellum (sensu Eukarya), ISS | 1 genes |
| fertilization, NAS | 1 genes |
| FMN binding, IDA | 1 genes |
| fatty acid transporter activity, TAS | 1 genes |
| fructose transport, TAS | 1 genes |
| folate transport, NAS | 1 genes |
| fatty acid transport, TAS | 1 genes |
| formate metabolism, NAS | 1 genes |
| formyltetrahydrofolate dehydrogenase activity, IEA | 1 genes |
| follicle-stimulating hormone activity, NAS | 1 genes |
| fatty acid oxidation, IDA | 1 genes |
| fatty acid oxidation, NAS | 1 genes |
| flagellum, IDA | 1 genes |
| fructosamine-3-kinase activity, NAS | 1 genes |
| fructoselysine metabolism, NAS | 1 genes |
| formimidoyltetrahydrofolate cyclodeaminase activity, IEA | 1 genes |
| fertilization, exchange of chromosomal proteins, TAS | 1 genes |
| flavin reductase activity, IEA | 1 genes |
| fucose-1-phosphate guanylyltransferase activity, IEA | 1 genes |
| focal adhesion formation, IDA | 1 genes |
| focal adhesion formation, ISS | 1 genes |
| FAD binding, IDA | 1 genes |
| FAD binding, NAS | 1 genes |
AS3D Human
