AS3D Human


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Human Gene Lists S
signal transduction, TAS551 genes
StructuralGenomics All Centers Purified Targets List432 genes
StructuralGenomics Soluble PSF Targets198 genes
SH3, SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta186 genes
signal transduction, IEA183 genes
structural molecule activity, IEA176 genes
small GTPase mediated signal transduction, IEA147 genes
soluble fraction, TAS138 genes
synaptic transmission, TAS128 genes
signal transducer activity, IEA124 genes
SCP-1, Synaptonemal complex protein 1 (SCP-1). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chro120 genes
structural constituent of ribosome, IEA100 genes
SH2, SH2 domain99 genes
SPRY, SPRY domain. SPRY Domain is named from SPla and the RYanodine Receptor. Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues97 genes
sugar binding, IEA96 genes
Sporozoite_P67, Sporozoite P67 surface antigen. This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the co85 genes
Sugar_tr, Sugar (and other) transporter80 genes
signal transduction, NR77 genes
skeletal development, TAS76 genes
SAM, SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potent71 genes
symporter activity, IEA66 genes
S-antigen, S-antigen protein. S-antigens are heat stable proteins that are found in the blood of individuals infected with malaria57 genes
SCAN, SCAN domain. The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerisation56 genes
signal transducer activity, TAS54 genes
structural constituent of ribosome, TAS53 genes
signal transduction, NAS52 genes
spermatogenesis, TAS51 genes
structural constituent of cytoskeleton, TAS50 genes
synaptic transmission, IEA50 genes
Sushi, Sushi domain (SCR repeat)48 genes
sodium ion transport, IEA48 genes
serine-type endopeptidase inhibitor activity, IEA43 genes
signal transducer activity, IMP43 genes
soluble fraction, NR43 genes
steroid hormone receptor activity, IEA39 genes
Serpin, Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich38 genes
SET, SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display simi38 genes
StructuralGenomics Purified PSF Targets38 genes
SH3/SH2 adaptor protein activity, TAS37 genes
structural molecule activity, TAS36 genes
Sulfotransfer_1, Sulfotransferase domain35 genes
SMN, Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a l35 genes
S-adenosylmethionine-dependent methyltransferase activity, IEA35 genes
SNF2_N, SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1) , DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RA30 genes
Sema, Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth facto29 genes
structural constituent of muscle, TAS29 genes
S_100, S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins28 genes
sugar porter activity, IEA27 genes
synaptic vesicle, IEA27 genes
synapse, IEA27 genes
Spectrin, Spectrin repeat. Spectrin repeats are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in 23 genes
SNARE, SNARE domain. Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) recepto23 genes
specific RNA polymerase II transcription factor activity, TAS23 genes
Syndecan, Syndecan domain. Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors22 genes
signal transducer activity, IEP22 genes
SRCR, Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions21 genes
Sulfatase, Sulfatase21 genes
serine-type endopeptidase inhibitor activity, TAS21 genes
structural molecule activity, NAS21 genes
small GTPase mediated signal transduction, TAS21 genes
SNF, Sodium:neurotransmitter symporter family20 genes
SelP_N, Selenoprotein P, N terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to 20 genes
scavenger receptor activity, IEA20 genes
steroid binding, IEA20 genes
sugar binding, TAS20 genes
sodium ion transport, TAS20 genes
SSDP, Single-stranded DNA binding protein, SSDP. This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene19 genes
spliceosome complex, IEA19 genes
spermatogenesis, NAS19 genes
SBP_bac_3, Bacterial extracellular solute-binding proteins, family 318 genes
structural constituent of ribosome, NAS18 genes
structural molecule activity, NR18 genes
SAP, SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA binding domain found in diverse nuclear proteins17 genes
Sas10_Utp3, Sas10/Utp3 family. This family contains Sas10 which hash been identified as a regulator of chromatin silencing. The family also contains Utp3 a component of the U3 ribonucleoprotein complex. The exact molecular function of this fam17 genes
Sigma70_ner, Sigma-70, non-essential region. The domain is found in the primary vegetative sigma factor. The function of this domain is unclear and can be removed without loss of function17 genes
structural constituent of cytoskeleton, NR17 genes
steroid metabolism, IEA17 genes
SAM_PNT, Sterile alpha motif (SAM)/Pointed domain16 genes
SCP, SCP-like extracellular protein. This domain is also found in prokaryotes15 genes
Sec7, Sec7 domain. The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family15 genes
SEA, SEA domain. Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains15 genes
START, START domain15 genes
structural constituent of cytoskeleton, IEA15 genes
spliceosome complex, TAS15 genes
synaptic transmission, NR15 genes
single-stranded DNA binding, TAS14 genes
serine-type endopeptidase activity, IEA14 genes
signal transducer activity, NR14 genes
striated muscle thick filament, IEA14 genes
spermatogenesis, IEA14 genes
synaptogenesis, TAS14 genes
SSP160, Special lobe-specific silk protein SSP160. This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species13 genes
signal transducer activity, NAS13 genes
structural constituent of eye lens, IEA13 genes
SSF, Sodium:solute symporter family. Membership of this family is supported by a significant blast score12 genes
serine esterase activity, IEA12 genes
serotonin receptor activity, TAS12 genes
small GTPase regulatory/interacting protein activity, IEA12 genes
striated muscle contraction, IEA12 genes
STAS, STAS domain. The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may h11 genes
SNF7, SNF7. This family consists of a group of SNF-7 homologues involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipid11 genes
spindle, TAS11 genes
Sulfate_transp, Sulfate transporter family. Mutations in the human diastrophic dysplasia protein lead to several diseases10 genes
Synaptobrevin, Synaptobrevin10 genes
Seryl_tRNA_N, Seryl-tRNA synthetase N-terminal domain. This domain is found associated with the Pfam tRNA synthetase class II domain (pfam00587) and represents the N-terminal domain of seryl-tRNA synthetase10 genes
SKN1, Beta-glucan synthesis-associated protein (SKN1). This family consists of the beta-glucan synthesis-associated proteins KRE6 and SKN1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-g10 genes
SDA1, SDA1. This family consists of several SDA1 protein homologues. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localised in the nuc10 genes
serine-type endopeptidase inhibitor activity, NAS10 genes
small nucleolar ribonucleoprotein complex, IEA10 genes
synaptic transmission, NAS10 genes
sex differentiation, IEA10 genes
sulfotransferase activity, IEA10 genes
sulfotransferase activity, TAS10 genes
synaptosome, IEA10 genes
SAND, SAND domain. The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerisation9 genes
Ssu72, Ssu72-like protein. The yeast Ssu72 is an essential protein that may be involved in transcription start site specification. Ssu72 is stably associated with yeast cleavage and polyadenylation factor CPF. There is evidence that it bridges9 genes
Sprouty, Sprouty protein (Spry). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental p9 genes
steroid hormone receptor activity, TAS9 genes
subtilase activity, IEA9 genes
signal transducer activity, ISS9 genes
steroid biosynthesis, IEA9 genes
superoxide metabolism, IEA9 genes
sensory perception, TAS9 genes
steroid metabolism, TAS9 genes
structural constituent of epidermis, NAS9 genes
S1, S1 RNA binding domain. The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure8 genes
Syntaxin, Syntaxin. Syntaxins are t-SNARES8 genes
Sec1, Sec1 family8 genes
STAT_alpha, STAT protein, all-alpha domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines 8 genes
SMC_N, RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil8 genes
SMC_C, SMC family, C-terminal domain. This Pfam family represents a conserved domain towards the C-terminus of the SMC family proteins. A second conserved domain is found at the N-terminus (pfam02463). The SMC (structural maintenance of chromo8 genes
SPAN-X, Sperm protein associated with nucleus, mapped to X chromosome (SPAN-X). This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins ar8 genes
sodium ion transport, NAS8 genes
smooth muscle contraction, NR8 genes
striated muscle contraction, TAS8 genes
small GTPase mediated signal transduction, NAS8 genes
spermatogenesis, ISS8 genes
synaptic vesicle, TAS8 genes
serine-type peptidase activity, IEA8 genes
sulfate transport, IEA8 genes
SDF, Sodium:dicarboxylate symporter family7 genes
Somatomedin_B, Somatomedin B domain7 genes
SIR2, Sir2 family7 genes
STAT_bind, STAT protein, DNA binding domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines7 genes
STAT_int, STAT protein, protein interaction domain. STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cy7 genes
Sulfotransfer_2, Sulfotransferase. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin7 genes
Sec6, Exocyst complex component Sec6. Sec6 is a component of the multiprotein exocyst complex. Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells an7 genes
SF-assemblin, SF-assemblin/beta giardin. This family consists of several eukaryotic SF-assemblin and related beta giardin proteins. During mitosis the SF-assemblin-based cytoskeleton is reorganised; it divides in prophase and is reduced to two7 genes
small GTPase regulatory/interacting protein activity, TAS7 genes
structural constituent of cytoskeleton, NAS7 genes
soluble fraction, NAS7 genes
signal recognition particle, IEA7 genes
signal transduction, ISS7 genes
synaptic transmission, cholinergic, TAS7 genes
spermatogenesis, IEP7 genes
synaptic vesicle, NR7 genes
sulfate porter activity, IEA7 genes
structural constituent of muscle, NAS7 genes
sulfuric ester hydrolase activity, IEA7 genes
sodium:dicarboxylate symporter activity, IEA7 genes
SBF, Sodium Bile acid symporter family. This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na6 genes
Surp, Surp module. This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding6 genes
Ski_Sno, SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphologica6 genes
Steroid_dh, 3-oxo-5-alpha-steroid 4-dehydrogenase. This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor 6 genes
Sec23_trunk, Sec23/Sec24 trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the sm6 genes
Sec23_helical, Sec23/Sec24 helical domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: th6 genes
SURF6, Surfeit locus protein 6. The surfeit locus protein SURF-6 is shown to be a component of the nucleolar matrix and has a strong binding capacity for nucleic acids6 genes
STOP, STOP protein. Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable microtubules are thought to be essential for neuronal development, maintenance, and 6 genes
Suf, Suppressor of forked protein (Suf). This family consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster Suppressor of forked [Su(f)] protein shares homology with the yeast RNA14 protein and the6 genes
SERTA, SERTA motif. This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins. The function of this motif is uncertain, but the CDK4-interacting 6 genes
scavenger receptor activity, TAS6 genes
structural constituent of cytoskeleton, ISS6 genes
sugar binding, NAS6 genes
sphingolipid metabolism, IEA6 genes
sex differentiation, TAS6 genes
sensory perception, IEA6 genes
spectrin, TAS6 genes
sialyltransferase activity, TAS6 genes
solute:hydrogen antiporter activity, IEA6 genes
SRF-TF, SRF-type transcription factor (DNA-binding and dimerisation domain)5 genes
SUI1, Translation initiation factor SUI15 genes
SCP2, SCP-2 sterol transfer family. This domain is involved in binding sterols. It is found in the SCP2 protein, as well as the C terminus of the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein contains an SPFH domain pf5 genes
SWIB, SWIB/MDM2 domain. This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to 5 genes
Syja_N, SacI homology domain. This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin5 genes
Spin-Ssty, Spin/Ssty Family. Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this5 genes
Sec63, Sec63 domain5 genes
Sterile, Male sterility protein. This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila. A sequence-related jojoba acyl CoA reductase is also included5 genes
SART-1, SART-1 family. This family of proteins appear to contain a leucine zipper and may therefore be a family of transcription factors5 genes
Scramblase, Scramblase. Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site. Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs5 genes
Sec62, Translocation protein Sec625 genes
Skp1_POZ, Skp1 family, tetramerisation domain5 genes
Spc97_Spc98, Spc97 / Spc98 family. The spindle pole body (SPB) functions as the microtubule-organising centre in yeast. Members of this family are spindle pole body (SBP) components such as Spc97 and Spc98 that form a complex with gamma-tubuli5 genes
SCAMP, SCAMP family. In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regio5 genes
SWIRM, SWIRM domain. This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. This domain is predicted to be a protein-protein interaction unit5 genes
SMC_hinge, SMC proteins Flexible Hinge Domain. This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is als5 genes
skeletal development, NAS5 genes
single-stranded DNA binding, NAS5 genes
somatostatin receptor activity, TAS5 genes
structural constituent of eye lens, NAS5 genes
sodium:phosphate symporter activity, TAS5 genes
smooth endoplasmic reticulum, TAS5 genes
steroid biosynthesis, TAS5 genes
sex determination, IEA5 genes
selenium binding, TAS5 genes
SH3 domain binding, IPI5 genes
sperm motility, ISS5 genes
structural constituent of tooth enamel, NAS5 genes
Serum_albumin, Serum albumin family4 genes
Stathmin, Stathmin family4 genes
Sterol_desat, Sterol desaturase. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain many conse4 genes
SelR, SelR domain. Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been kn4 genes
Synapsin_C, Synapsin, ATP binding domain. Ca dependent ATP binding in this ATP grasp fold. Function unknown4 genes
Succ_DH_flav_C, Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain. This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases4 genes
Str_synth, Strictosidine synthase. Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyses the condensation of tryptamine with secologanin to form strictosidine4 genes
Sina, Seven in absentia protein family. The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of funct4 genes
Sp100, Sp100 domain. The function of this domain is unknown. It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND do4 genes
SapB_2, Saposin-like type B, region 24 genes
S10_plectin, Plectin/S10 domain. This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding4 genes
SK_channel, Calcium-activated SK potassium channel4 genes
Sybindin, Sybindin-like family. Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses4 genes
SAB, SAB domain. This presumed domain is found in proteins containing FERM domains pfam00373. This domain is found to bind to both spectrin and actin, hence the name SAB (Spectrin and Actin Binding) domain4 genes
SAPS, SIT4 phosphatase-associated protein. This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud for4 genes
Sarcoglycan_1, Sarcoglycan complex subunit protein. The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex wi4 genes
SH3BGR, SH3-binding, glutamic acid-rich protein4 genes
Skb1, Skb1 methyltransferase. The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is a protein methyltransferase. These proteins seem to play a role in Jak signalling4 genes
synaptonemal complex, TAS4 genes
serine-type endopeptidase inhibitor activity, NR4 genes
signal sequence binding, TAS4 genes
sodium:potassium-exchanging ATPase activity, TAS4 genes
smooth endoplasmic reticulum, NR4 genes
spindle microtubule, TAS4 genes
sodium:potassium-exchanging ATPase complex, TAS4 genes
sodium ion transport, ISS4 genes
smooth muscle contraction, NAS4 genes
signal complex formation, TAS4 genes
spermatogenesis, NR4 genes
spermatid development, TAS4 genes
sex determination, TAS4 genes
store-operated calcium channel activity, TAS4 genes
sodium-dependent phosphate transporter activity, TAS4 genes
small ribosomal subunit, IEA4 genes
sarcoglycan complex, TAS4 genes
sarcoplasmic reticulum, IEA4 genes
small nuclear ribonucleoprotein complex, TAS4 genes
synapse, ISS4 genes
Sod_Cu, Copper/zinc superoxide dismutase (SODC). superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copp3 genes
SAA, Serum amyloid A protein3 genes
SpoU_methylase, SpoU rRNA Methylase family. This family of proteins probably use S-AdoMet3 genes
SIS, SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Pr3 genes
Synuclein, Synuclein. There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also 3 genes
SAM_decarbox, Adenosylmethionine decarboxylase. This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes. In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl mo3 genes
Spermine_synth, Spermine/spermidine synthase. Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase3 genes
Synapsin_N, Synapsin, N-terminal domain3 genes
Sorb, Sorbin homologous domain3 genes
STT3, Oligosaccharyl transferase STT3 subunit. This family consists of the oligosaccharyl transferase STT3 subunit and related proteins. The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for3 genes
S-methyl_trans, Homocysteine S-methyltransferase. This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases also known EC:2.1.1.13; Betaine--homocysteine S-methyltransfer3 genes
STAG, Stromal antigen (SA/STAG) protein3 genes
SAC3_GANP, SAC3/GANP family. This family of eukaryotic proteins brings together the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates wit3 genes
SMP-30, Senescence marker protein-30 (SMP-30). SMP-30, also known as regucalcin, seems to play a critical role in the highly differentiated functions of the liver and kidney and to exert a major impact on Ca2+ homeostasis3 genes
ST7, ST7 protein. The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain3 genes
Securin, Securin sister-chromatid separation inhibitor. Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to er3 genes
SSXT, SSXT protein (N-terminal region). The SSXT or SS18 protein is involved in synovial sarcoma in humans. A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This trans3 genes
Synaphin, Synaphin protein. This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precom3 genes
Sec10, Exocyst complex component Sec10. This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which specifically affects the synthesis and delivery of secretory and basolateral plasma mem3 genes
spliceosome assembly, NAS3 genes
spliceosomal snRNP biogenesis, TAS3 genes
spindle pole, IDA3 genes
skeletal development, ISS3 genes
skeletal development, NR3 genes
single-stranded DNA binding, IDA3 genes
single-stranded DNA binding, ISS3 genes
single-stranded DNA binding, NR3 genes
structural constituent of ribosome, NR3 genes
superoxide dismutase activity, IEA3 genes
SH3/SH2 adaptor protein activity, IDA3 genes
sugar porter activity, NAS3 genes
sodium:potassium-exchanging ATPase activity, ISS3 genes
steroid binding, TAS3 genes
sterol carrier activity, IEA3 genes
soluble fraction, IDA3 genes
soluble fraction, ISS3 genes
spliceosome complex, NAS3 genes
small nucleolar ribonucleoprotein complex, NAS3 genes
signal recognition particle, TAS3 genes
spindle pole body, TAS3 genes
sodium:potassium-exchanging ATPase complex, ISS3 genes
SRP-dependent cotranslational membrane targeting, IEA3 genes
superoxide metabolism, NR3 genes
substrate-bound cell migration, cell extension, TAS3 genes
smooth muscle contraction, TAS3 genes
synaptic transmission, ISS3 genes
spermatid development, NAS3 genes
sulfate transport, TAS3 genes
sialyltransferase activity, IEA3 genes
steroid hydroxylase activity, TAS3 genes
snRNA transcription, TAS3 genes
sterol transporter activity, TAS3 genes
sodium-independent organic anion transporter activity, TAS3 genes
sodium:hydrogen antiporter activity, TAS3 genes
small conductance calcium-activated potassium channel activity, IEA3 genes
specific transcriptional repressor activity, TAS3 genes
second-messenger-mediated signaling, NAS3 genes
secretory granule, IEA3 genes
SecY, eubacterial secY protein2 genes
S-AdoMet_synt_N, S-adenosylmethionine synthetase, N-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold2 genes
SRP54, SRP54-type protein, GTPase domain. This family includes relatives of the G-domain of the SRP54 family of proteins2 genes
SHMT, Serine hydroxymethyltransferase2 genes
SNAP-25, SNAP-25 family. SNAP-25 (synaptosome-associated protein 25 kDa) proteins are components of SNARE complexes. Members of this family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment2 genes
SKI, Shikimate kinase2 genes
Skp1, Skp1 family, dimerisation domain2 genes
S4, S4 domain. The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA m2 genes
SURF4, SURF4 family2 genes
SURF1, SURF1 family2 genes
SapA, Saposin A-type domain2 genes
SRP14, Signal recognition particle 14kD protein. The signal recognition particle (SRP) is a multimeric protein involved in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP14 and SRP9 form a complex essential for SR2 genes
SCO1-SenC, SCO1/SenC. This family is involved in biogenesis of respiratory and photosynthetic systems. SCO1 is required for a post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase. SenC is required for 2 genes
S-AdoMet_synt_M, S-adenosylmethionine synthetase, central domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold2 genes
S-AdoMet_synt_C, S-adenosylmethionine synthetase, C-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold2 genes
SPX, SPX domain. We have named this region the SPX domain after (SYG1, Pho81 and XPR1). This 180 residue length domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G- 2 genes
Stanniocalcin, Stanniocalcin family2 genes
Saccharop_dh, Saccharopine dehydrogenase. This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reduct2 genes
Smg4_UPF3, Smg-4/UPF3 family. This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 and UPF32 genes
Sorting_nexin, Sorting nexin, N-terminal domain. These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking. The N-terminal domain appears to be specific to sorting nexins 1 an2 genes
Sec20, Sec20. Sec20 is a membrane glycoprotein associated with secretory pathway2 genes
Ssl1, Ssl1-like. Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex2 genes
SRP-alpha_N, Signal recognition particle, alpha subunit, N-terminal. SRP is a complex of six distinct polypeptides and a 7S RNA that is essential for transferring nascent polypeptide chains that are destined for export from the cell to the tra2 genes
Sec15, Exocyst complex subunit Sec15-like2 genes
Sedlin_N, Sedlin, N-terminal conserved region. Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region2 genes
SOUL, SOUL heme-binding protein. This family represents a group of putative heme-binding proteins. Our family includes archaeal and bacterial homologues2 genes
SGS, SGS domain. This domain was thought to be unique to the SGT1-like proteins, but is also found in calcyclin binding proteins2 genes
SapB_1, Saposin-like type B, region 12 genes
SH3BP5, SH3 domain-binding protein 5 (SH3BP5). This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vit2 genes
Sclerostin, Sclerostin (SOST). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an aut2 genes
Semenogelin, Semenogelin. This family consists of several mammalian semenogelin (I and II) proteins. Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicl2 genes
Sarcoglycan_2, Sarcoglycan alpha/epsilon. Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies h2 genes
SLA_LP_auto_ag, Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). This family consists of several eukaryotic and archaeal proteins which are related to the human soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen2 genes
SURF5, Surfeit locus protein 5. This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1. The locus includes six tightly clustered housekeeping genes (Su2 genes
Sec2p, GDP/GTP exchange factor Sec2p. In Saccharomyces cerevisiae, Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion2 genes
Spond_N, Spondin_N. This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells2 genes
SIM_C, Single-minded protein C-terminus. This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation.2 genes
Strabismus, Strabismus protein. This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppr2 genes
SPC25, Microsomal signal peptidase 25 kDa subunit (SPC25). This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by 2 genes
SerH, Cell surface immobilisation antigen SerH. This family consists of several cell surface immobilisation antigen SerH proteins which seem to be specific to Tetrahymena thermophila. The SerH locus of Tetrahymena thermophila is one of several2 genes
Spot_14, Thyroid hormone-inducible hepatic protein Spot 14. This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesise triglycerides, the mRNA coding for Sp2 genes
SGT1, SGT1 protein. This family consists of several eukaryotic SGT1 proteins. Human SGT1 or hSGT1 is known to suppress GCR2 and is highly expressed in the muscle and heart. The function of this family is unknown although it has been speculated2 genes
SpoIIE, Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is h2 genes
Sp38, Zona-pellucida-binding protein (Sp38). This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a c2 genes
single-stranded DNA specific endodeoxyribonuclease activity, TAS2 genes
S phase of mitotic cell cycle, TAS2 genes
sulfate assimilation, IEA2 genes
spliceosome assembly, TAS2 genes
satellite DNA binding, TAS2 genes
single-stranded DNA binding, IEA2 genes
specific RNA polymerase II transcription factor activity, NR2 genes
single-stranded RNA binding, NR2 genes
single-stranded RNA binding, TAS2 genes
serine carboxypeptidase activity, IEA2 genes
subtilase activity, TAS2 genes
steroid 11-beta-monooxygenase activity, TAS2 genes
serine C-palmitoyltransferase activity, TAS2 genes
serine esterase activity, TAS2 genes
spermidine synthase activity, TAS2 genes
sphingomyelin phosphodiesterase activity, TAS2 genes
steroid delta-isomerase activity, TAS2 genes
sterol O-acyltransferase activity, IEA2 genes
sulfate adenylyltransferase (ATP) activity, ISS2 genes
signal recognition particle binding, TAS2 genes
SH3/SH2 adaptor protein activity, NR2 genes
structural constituent of chorion (sensu Insecta), IEA2 genes
serotonin-activated cation-selective channel activity, TAS2 genes
sodium channel activity, IEA2 genes
sodium:potassium-exchanging ATPase activity, IEA2 genes
SNAP receptor activity, TAS2 genes
sterol carrier activity, TAS2 genes
snRNP U5, TAS2 genes
snRNP U2, TAS2 genes
signal recognition particle receptor complex, TAS2 genes
sphingomyelin biosynthesis, IDA2 genes
steroid biosynthesis, NAS2 genes
superoxide metabolism, TAS2 genes
smooth muscle contraction, IEA2 genes
striated muscle contraction, NAS2 genes
synaptonemal complex formation, TAS2 genes
signal transduction, IDA2 genes
signal complex formation, NAS2 genes
SMAD protein heteromerization, TAS2 genes
STAT protein nuclear translocation, TAS2 genes
spermatid development, ISS2 genes
synaptogenesis, NAS2 genes
sex differentiation, NAS2 genes
sensory perception, NR2 genes
sensory perception of chemical stimulus, TAS2 genes
synaptic vesicle, ISS2 genes
sulfotransferase activity, NAS2 genes
structural constituent of bone, NR2 genes
sulfonylurea receptor activity, TAS2 genes
spermidine biosynthesis, IEA2 genes
structural constituent of muscle, NR2 genes
sodium:bicarbonate symporter activity, NAS2 genes
sodium:potassium:chloride symporter activity, TAS2 genes
sodium ion transporter activity, TAS2 genes
sarcoglycan complex, IEA2 genes
synaptic vesicle docking, NAS2 genes
sterol biosynthesis, IEA2 genes
structural constituent of nuclear pore, IEA2 genes
SH3 domain binding, NAS2 genes
semaphorin receptor activity, TAS2 genes
syntaxin binding, IEA2 genes
second-messenger-mediated signaling, ISS2 genes
sexual reproduction, IEA2 genes
sarcomere, TAS2 genes
sphingolipid catabolism, NAS2 genes
solute:solute exchange, NAS2 genes
sperm motility, IMP2 genes
superoxide release, IDA2 genes
secretory pathway, IEP2 genes
Sod_Fe_N, Iron/manganese superoxide dismutases, alpha-hairpin domain. superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are kno1 genes
Sigma54_activat, Sigma-54 interaction domain1 genes
SSB, Single-strand binding protein family. This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA1 genes
SQS_PSY, Squalene/phytoene synthase1 genes
SNase, Staphylococcal nuclease homologue. Present in all three domains of cellular life. Four copies in the transcriptional coactivator p100: these, however, appear to lack the active site residues of Staphylococcal nuclease. Positions 14 (Asp1 genes
SecE, SecE/Sec61-gamma subunits of protein translocation complex. SecE is part of the SecYEG complex in bacteria which translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha translocates prot1 genes
Sdh_cyt, Succinate dehydrogenase cytochrome b subunit1 genes
SAICAR_synt, SAICAR synthetase. Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase1 genes
Sua5_yciO_yrdC, yrdC domain. This domain has been shown to preferentially bind to dsRNA. The domain is found in SUA5 as well as HypF and YrdC1 genes
SLT, Transglycosylase SLT domain. This family is distantly related to pfam000621 genes
Shikimate_DH, Shikimate / quinate 5-dehydrogenase. This family contains both shikimate and quinate dehydrogenases. Shikimate 5-dehydrogenase catalyses the conversion of shikimate to 5-dehydroshikimate. This reaction is part of the shikimate pa1 genes
Smr, Smr domain. This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-ter1 genes
SRP19, SRP19 protein. The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytop1 genes
SPAM, Salmonella surface presentation of antigen gene type M protein1 genes
Srg, C.elegans Srg family integral membrane protein1 genes
SCF, Stem cell factor. Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential recept1 genes
SKIP_SNW, SKIP/SNW domain. This domain is found in chromatin proteins1 genes
Sod_Fe_C, Iron/manganese superoxide dismutases, C-terminal domain. superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known,1 genes
SRP54_N, SRP54-type protein, helical bundle domain1 genes
SRP_SPB, Signal peptide binding domain1 genes
Somatostatin, Somatostatin/Cortistatin family. Members of this family are hormones. Somatostatin inhibits the release of somatotropin. Cortistatin is a peptide that is related to the Somatostatins that is found to depresses neuronal electrical1 genes
SP2, Structural protein 2. This family represents structural protein 2 of the hepatitis E virus. The high basic amino acid content of this protein has lead to the suggestion of a role in viral genomic RNA encapsidation1 genes
Sre, C. elegans Sre G protein-coupled chemoreceptor. Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognised groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra pfam021171 genes
Supt5, Supt5 repeat. This short region of similarity is found in two tandem copies in Supt5 proteins that are involved in chromatin regulation. The function of this region is unknown1 genes
SIC, sic protein. Serotype M1 group A Streptococcus strains cause epidemic waves of human infections. This family includes the sic protein an extracellular protein (streptococcal inhibitor of complement) that inhibits human complement1 genes
SSrecog, Structure-specific recognition protein1 genes
SPO11_like, SPO11 homologue1 genes
Spore_permease, Spore germination protein1 genes
Statherin, Statherin. Statherin functions biologically to inhibit the nucleation and growth of calcium phosphate minerals. The N-terminus of statherin is highly charge, the glutamic acids of which have been shown to be important in the recogni1 genes
Sec61_beta, Sec61beta family. This family consists of homologues of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG1 genes
Sec8_exocyst, Sec8 exocyst complex component specific domain1 genes
Sec34, Sec34-like family. Sec34 and Sec35 form a sub-complex, in a seven protein complex that includes Dor1 (pfam04124). This complex is thought to be important for tether vesicles to the Golgi1 genes
Sof1, Sof1-like domain. Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery1 genes
SoxG, Sarcosine oxidase, gamma subunit family. Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+). This enzyme catalyses the oxidative demethylation of sarcosine to y1 genes
Serglycin, Serglycin. Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule proteoglycan1 genes
SWIM, SWIM zinc finger1 genes
SPC22, Signal peptidase subunit. Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secret1 genes
SelP_C, Selenoprotein P, C terminal region. SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma. It is thought to 1 genes
Sin_N, Sin-like protein conserved region. Family of higher eukaryotic proteins. SIN was identified as a protein that interacts specifically with SXL (sex lethal) in a yeast two-hybrid assay. The interaction is mediated by one of the SXL RNA bi1 genes
SNF5, SNF5 / SMARCB1 / INI1. SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class c1 genes
SHQ1, SHQ1 protein. S. cerevisiae SHQ1 protein is required for SnoRNAs of the box H/ACA Quantitative accumulation (unpublished)1 genes
SIP1, Survival motor neuron (SMN) interacting protein 1 (SIP1). Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein 1 genes
SRP40_C, SRP40, C-terminal domain. This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologues. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant1 genes
SUFU, Suppressor of fused protein (SUFU). SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting1 genes
Seleno_W_rel, Selenoprotein W-related family. Selenoprotein W contains selenium as selenocysteine in the primary protein structure and levels of this selenoprotein are affected by selenium. The precise role of this family is unclear1 genes
Secretogranin_V, Neuroendocrine protein 7B2 precursor (Secretogranin V). The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many p1 genes
Sperm_Ag_HE2, Sperm antigen HE2. This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory prote1 genes
SVA, Seminal vesicle autoantigen (SVA). This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory 1 genes
SIN1, Stress-activated map kinase interacting protein 1 (SIN1). This family consists of several stress-activated map kinase interacting protein 1 (MAPKAP1 OR SIN1) sequences. The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase i1 genes
Siva, Cd27 binding protein (Siva). Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an imp1 genes
SURF2, Surfeit locus protein 2 (SURF2). Surfeit locus protein 2 is part of a group of at least six sequence unrelated genes (Surf-1 to Surf-6). The six Surfeit genes have been classified as housekeeping genes, being expressed in all tissue typ1 genes
SRP9, Signal recognition particle 9 kDa protein (SRP9). This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of syn1 genes
SOH1, SOH1. The family consists of Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant and has been found to be a component of the RNA polymerase II transcription 1 genes
SBP56, 56kDa selenium binding protein (SBP56). This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 partic1 genes
Sld5, Synthetic lethal mutants of dpb11-1 five. The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts. This 100 kD stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found a1 genes
Subtilisin_N, Subtilisin N-terminal Region. This family is found at the N-terminus of a number of subtilisins. It is cleaved prior to activation of the enzyme1 genes
Spt4, Transcription initiation protein Spt4. This family consists of several eukaryotic transcription initiation Spt4 proteins. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for tr1 genes
SLAM, Signaling lymphocytic activation molecule (SLAM) protein. This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-1 genes
SAP18, Sin3 associated polypeptide p18 (SAP18). This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repressi1 genes
SPC12, Microsomal signal peptidase 12 kDa subunit (SPC12). This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by 1 genes
Sugar_transport, Sugar transport protein. This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane prot1 genes
Senescence, Senescence-associated protein. This family contains a number of plant senescence-associated proteins of approximately 450 residues in length. In Hemerocallis, petals have a genetically based program that leads to senescence and cel1 genes
SAP_155, Splicing factor 3B subunit 1 (Spliceosome associated protein 155). This family represents a conserved region approximately 100 residues long within eukaryotic splicing factor 3B subunit 1 (Spliceosome associated protein 155). This is 1 genes
Selenoprotein_S, Selenoprotein S (SelS). This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. The function of this family is unknow1 genes
SF3b10, Splicing factor 3B subunit 10 (SF3b10). This family consists of several eukaryotic splicing factor 3B subunit 10 (SF3b10) proteins. SF3b10 is a 10 kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a a1 genes
SNURF, SNURF/RPN4 protein. This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested th1 genes
Spp-24, Secreted phosphoprotein 24 (Spp-24). This family represents a conserved region approximately 140 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein f1 genes
single strand break repair, IDA1 genes
single strand break repair, NR1 genes
single strand break repair, TAS1 genes
sulfur amino acid metabolism, TAS1 genes
succinate dehydrogenase activity, IEA1 genes
S-phase-specific transcription in mitotic cell cycle, TAS1 genes
SNARE binding, TAS1 genes
spliceosome assembly, IEA1 genes
synaptonemal complex, NAS1 genes
septin ring assembly, TAS1 genes
skeletal development, IMP1 genes
stress fiber, NAS1 genes
satellite DNA binding, NAS1 genes
steroid hormone receptor activity, NAS1 genes
steroid hormone receptor activity, NR1 genes
single-stranded RNA binding, ISS1 genes
structural constituent of ribosome, ISS1 genes
stromelysin 1 activity, TAS1 genes
stromelysin 3 activity, TAS1 genes
serine-type endopeptidase activity, TAS1 genes
squalene monooxygenase activity, NAS1 genes
steroid 17-alpha-monooxygenase activity, TAS1 genes
steroid 21-monooxygenase activity, IEA1 genes
sucrose alpha-glucosidase activity, IEA1 genes
selenide, water dikinase activity, IEA1 genes
selenide, water dikinase activity, NAS1 genes
sepiapterin reductase activity, TAS1 genes
serine esterase activity, NAS1 genes
serine-pyruvate transaminase activity, IEA1 genes
shikimate kinase activity, IEA1 genes
sphingomyelin phosphodiesterase activity, IEA1 genes
stearoyl-CoA 9-desaturase activity, IEA1 genes
stearoyl-CoA 9-desaturase activity, TAS1 genes
steroid delta-isomerase activity, IEA1 genes
sterol esterase activity, IEA1 genes
sterol esterase activity, NAS1 genes
steryl-sulfatase activity, TAS1 genes
succinate-CoA ligase (ADP-forming) activity, TAS1 genes
succinate-CoA ligase (GDP-forming) activity, IEA1 genes
succinate-CoA ligase (GDP-forming) activity, NAS1 genes
succinate-semialdehyde dehydrogenase activity, TAS1 genes
sulfinoalanine decarboxylase activity, IEA1 genes
serine-tRNA ligase activity, ISS1 genes
serine-tRNA ligase activity, TAS1 genes
signal transducer activity, IGI1 genes
serotonin receptor activity, NR1 genes
scavenger receptor activity, IDA1 genes
scavenger receptor activity, ISS1 genes
scavenger receptor activity, NAS1 genes
signal recognition particle binding, NR1 genes
SH3/SH2 adaptor protein activity, IPI1 genes
SH3/SH2 adaptor protein activity, NAS1 genes
small GTPase regulatory/interacting protein activity, NAS1 genes
sevenless binding, IEA1 genes
stem cell factor receptor binding, TAS1 genes
structural constituent of cell wall, IEA1 genes
structural constituent of cytoskeleton, IEP1 genes
structural constituent of eye lens, NR1 genes
sodium:amino acid symporter activity, IEA1 genes
sodium:amino acid symporter activity, NAS1 genes
serotonin:sodium symporter activity, IEA1 genes
sodium:potassium-exchanging ATPase activity, IDA1 genes
steroid binding, NR1 genes
sugar binding, IDA1 genes
sugar binding, NR1 genes
spliceosome complex, IDA1 genes
snRNP U1, NR1 genes
snRNP U1, TAS1 genes
snRNP U6, TAS1 genes
small nucleolar ribonucleoprotein complex, TAS1 genes
signal peptidase complex, TAS1 genes
smooth endoplasmic reticulum, ISS1 genes
spindle, IDA1 genes
striated muscle thin filament, NAS1 genes
sodium:potassium-exchanging ATPase complex, NAS1 genes
septate junction, NR1 genes
starch catabolism, TAS1 genes
sorbitol metabolism, NR1 genes
succinyl-CoA metabolism, NAS1 genes
succinyl-CoA metabolism, NR1 genes
snRNA-nucleus export, NAS1 genes
seryl-tRNA aminoacylation, IEA1 genes
seryl-tRNA aminoacylation, ISS1 genes
signal peptide processing, IEA1 genes
S-adenosylmethionine biosynthesis, IDA1 genes
S-adenosylmethionine biosynthesis, ISS1 genes
serotonin biosynthesis from tryptophan, NR1 genes
spermine biosynthesis, NAS1 genes
snRNP protein-nucleus import, ISS1 genes
snRNP protein-nucleus import, TAS1 genes
sphingolipid metabolism, TAS1 genes
sphinganine-1-phosphate biosynthesis, NAS1 genes
sphingomyelin metabolism, TAS1 genes
sphingomyelin catabolism, IEA1 genes
sphingomyelin catabolism, TAS1 genes
sphingomyelin biosynthesis, NAS1 genes
steroid biosynthesis, ISS1 genes
steroid biosynthesis, NR1 genes
steroid catabolism, TAS1 genes
succinyl-CoA pathway, NAS1 genes
sulfur metabolism, IEA1 genes
sulfur metabolism, NAS1 genes
superoxide metabolism, IDA1 genes
superoxide metabolism, ISS1 genes
serotonin transport, TAS1 genes
sodium ion homeostasis, NAS1 genes
sodium ion homeostasis, NR1 genes
substrate-bound cell migration, NR1 genes
substrate-bound cell migration, TAS1 genes
substrate-bound cell migration, cell extension, NAS1 genes
sarcomere alignment, TAS1 genes
smooth muscle contraction, IEP1 genes
sterol depletion response, sterol regulatory element binding-protein cleavage, NR1 genes
sterol depletion response, SREBP target gene transcriptional activation, IMP1 genes
sister chromatid cohesion, IC1 genes
sister chromatid cohesion, NAS1 genes
sister chromatid cohesion, TAS1 genes
synaptonemal complex formation, IEA1 genes
synaptonemal complex formation, NAS1 genes
SMAD protein nuclear translocation, TAS1 genes
serotonin receptor signaling pathway, NR1 genes
serotonin receptor signaling pathway, TAS1 genes
STAT protein nuclear translocation, NR1 genes
small GTPase mediated signal transduction, IC1 genes
spermatogenesis, IMP1 genes
spermatid nuclear elongation, IMP1 genes
sperm displacement, TAS1 genes
segment specification, TAS1 genes
synaptogenesis, ISS1 genes
sensory organ development, TAS1 genes
somatic muscle development, NAS1 genes
sex determination, NR1 genes
sugar utilization, NR1 genes
sensory perception, ISS1 genes
spectrin, IDA1 genes
spectrin, IEP1 genes
spectrin, NAS1 genes
synaptic vesicle endocytosis, IEA1 genes
synaptic vesicle endocytosis, TAS1 genes
sarcosine oxidase activity, IEA1 genes
sphinganine-1-phosphate aldolase activity, NAS1 genes
sulfotransferase activity, IDA1 genes
structural constituent of bone, NAS1 genes
structural constituent of bone, TAS1 genes
succinate dehydrogenase (ubiquinone) activity, IEA1 genes
signalosome complex, IEA1 genes
steroid metabolism, NR1 genes
serine-type peptidase activity, ISS1 genes
serine-type peptidase activity, NAS1 genes
sulfate transport, NAS1 genes
sulfonylurea receptor activity, IEA1 genes
spermidine biosynthesis, NAS1 genes
structural constituent of muscle, IEA1 genes
site-specific DNA-methyltransferase (cytosine-specific) activity, TAS1 genes
sterol 12-alpha-hydroxylase activity, TAS1 genes
sterol 14-demethylase activity, NR1 genes
selenium binding, IEA1 genes
sarcosine dehydrogenase activity, TAS1 genes
sphinganine kinase activity, NAS1 genes
sulfite oxidase activity, TAS1 genes
sodium-dependent multivitamin transporter activity, NAS1 genes
sodium-dependent multivitamin transporter activity, TAS1 genes
sodium-exporting ATPase activity, phosphorylative mechanism, TAS1 genes
small protein conjugating enzyme activity, TAS1 genes
S-adenosylmethionine-dependent methyltransferase activity, IDA1 genes
S-adenosylmethionine-dependent methyltransferase activity, TAS1 genes
selenocysteine lyase activity, TAS1 genes
secretin receptor activity, TAS1 genes
serotonin transporter activity, TAS1 genes
symporter activity, NAS1 genes
solute:cation symporter activity, TAS1 genes
solute:hydrogen antiporter activity, TAS1 genes
solute:solute antiporter activity, NAS1 genes
sodium-dependent phosphate transporter activity, IEA1 genes
sodium:chloride symporter activity, TAS1 genes
sodium:sulfate symporter activity, TAS1 genes
sodium:hydrogen antiporter activity, IDA1 genes
sodium:hydrogen antiporter activity, IEA1 genes
sodium:hydrogen antiporter activity, ISS1 genes
small ribosomal subunit, NAS1 genes
syntrophin complex, TAS1 genes
synaptic vesicle exocytosis, TAS1 genes
synaptic vesicle targeting, ISS1 genes
sterol metabolism, IEA1 genes
sterol biosynthesis, NAS1 genes
superoxide-generating NADPH oxidase activity, IDA1 genes
superoxide-generating NADPH oxidase activity, TAS1 genes
synaptic vesicle transport, ISS1 genes
synaptic vesicle transport, NAS1 genes
synaptic vesicle maturation, NAS1 genes
selenocysteine biosynthesis, NAS1 genes
small conductance calcium-activated potassium channel activity, TAS1 genes
somatic hypermutation of antibody genes, NAS1 genes
SWI/SNF complex, IDA1 genes
SWI/SNF complex, ISS1 genes
sarcoplasmic reticulum, IDA1 genes
specific transcriptional repressor activity, IDA1 genes
specific transcriptional repressor activity, ISS1 genes
Srb-mediator complex, NAS1 genes
spermine synthase activity, IEA1 genes
strictosidine synthase activity, IEA1 genes
SAP kinase 3 activity, IDA1 genes
SUMO-specific protease activity, IDA1 genes
S-methyl-5-thioadenosine phosphorylase activity, IEA1 genes
syntaxin-1 binding, NAS1 genes
syntaxin-1 binding, TAS1 genes
sodium channel regulator activity, IDA1 genes
sodium channel regulator activity, NAS1 genes
SH3 domain binding, ISS1 genes
SH3 domain binding, TAS1 genes
synaptosome, NAS1 genes
stem cell maintenance, TAS1 genes
syntaxin binding, NAS1 genes
structural constituent of myelin sheath, IEA1 genes
sexual reproduction, IMP1 genes
sarcomere, NAS1 genes
secretory granule, ISS1 genes
secretory granule, NAS1 genes
secretory granule, TAS1 genes
sodium:calcium exchange, NAS1 genes
semaphorin receptor binding, TAS1 genes
sphingolipid activator protein activity, NAS1 genes
stromelysin 2 activity, IEA1 genes
sperm motility, IDA1 genes
sperm motility, NAS1 genes
sperm motility, TAS1 genes
structural constituent of tooth enamel, ISS1 genes
syntaxin-2 binding, NAS1 genes
syntaxin-3 binding, NAS1 genes
syntaxin-13 binding, TAS1 genes
sleep, ISS1 genes
spectrin binding, ISS1 genes
spectrin binding, NAS1 genes
steroid hormone receptor signaling pathway, NAS1 genes
snoRNP binding, ISS1 genes
small nuclear ribonucleoprotein complex, IEA1 genes
subapical complex, IDA1 genes
SH2 domain binding, IPI1 genes
SH2 domain binding, ISS1 genes
superoxide release, ISS1 genes
superoxide release, NAS1 genes
sequestering of actin monomers, TAS1 genes
surfactant homeostasis, IMP1 genes
single-stranded DNA-dependent ATPase activity, IDA1 genes
secretory pathway, IDA1 genes
secretory pathway, ISS1 genes
secretory pathway, TAS1 genes
synapse, IDA1 genes
synapse, NAS1 genes
syndecan binding, NAS1 genes
SMAD binding, NAS1 genes
sphingoid catabolism, ISS1 genes
saliva secretion, NAS1 genes
secretion, ISS1 genes
secretion, NAS1 genes
saccharopine dehydrogenase (NADP+, L-lysine-forming) activity, IEA1 genes
saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity, IEA1 genes
S100 beta binding, IPI1 genes
S100 alpha binding, IPI1 genes
sperm capacitation, ISS1 genes
syntaxin-6 binding, ISS1 genes
spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase, TAS1 genes
AS3D: Alternative Splicing Structural Genomics Projects
CARB/UMBI